The Effect of Cosolvents and Surfactants on the Aqueous Solubility of Irbesartan
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Abstract
It was considered an interest to enhance the aqueous solubility of irbesartan. To accomplish this objective, the solubilization of irbesartan by cosolvency and micellization was investigated. It was found that all the cosolvents (ethanol, glycerol, propylene glycol) and surfactants (sodium lauryl sulfate, polysorbate-80) increased the solubility of irbesartan. Sodium lauryl sulfate was observed to be the most effective of the solubilizing agents used. The increase in aqueous solubility of irbesartan at the maximum concentration studied was in the following order: sodium lauryl sulfate > polysorbate-80 > ethanol > propylene glycol > glycerol.
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