Therapeutic Symphony: Annona muricata Extract Orchestrates Metabolic Resilience in Mammary Carcinogenesis.

Abstract

Abstract

Breast cancer is still a major global health concern and is caused by a combination of hormonal, environmental, and inheritable factors. 7,12- Dimethylbenz( a) anthracene( DMBA) is a major contributor to the development of mammary cancer. This study demonstrated that the  Anona muricata orchestrates metabolic adaptability in mammary carcinogenesis. The study focuses on specific enzymes pivotal to cancer metabolic pathways to provide an understanding of breast carcinogenesis. The implicit remedial benefits of Annona muricata are studied by carefully examining the following enzymes Glucose-6-Phosphate Dehydrogenase, Glutamate Dehydrogenase, Glutaminase, Hexokinase 2, Pyruvate Kinase M2, Lactate Dehydrogenase A, Matrix Metalloproteinases, Superoxide Dismutase, Glutathione Peroxidase, and Catalase. The safety of the bioactive substances present in the  Annona muricata was evaluated by oral acute toxicity testing. Mature albino Wistar rats were separated into experimental groups and were given DMBA injections before treating them with   Annona muricata  The effect of the extract on particular enzymes central to cancer metabolism and antioxidant enzyme pointers was estimated. The results showed a substantial increase in these enzyme levels after DMBA induction, which could indicate metabolic changes connected to cancer. The Annona muricata treated groups reached nearly normal enzyme levels when given at 100 and 250 mg/ kg body weight,  suggesting a remedial benefit. Histopathological study revealed that the Annona muricata effectively treated tumor-related issues and averted tumor incursion. The study concludes that Annona muricata has the implicit to impact the biochemical pathways linked to cancer and slow the growth of breast tumors. The need for further mechanistic exploration is one of the limitations of the study therefore additional studies should estimate the safety and effectiveness of this treatment in human subjects while concentration on the possibility of synergizing it with traditional cancer treatments